The INFO+ approach also requires 1–3 orders of magnitude less in computation, compared to appropriate baselines, making it feasible to explore datasets larger than ever before. It can be thought of as a measure of the natural history of the disease. The challenge can be seen in two halves: identifying predictive markers, which guide the development/use of tailored therapies; and identifying prognostic markers, which guide other aspects of care and clinical trial planning, i.e. Descriptive Vs Predictive The Author tried to explain three concepts and He did an excellent job. Prognostic and Predictive Profiling.