MAOI therapy Due to the risk for serotonin syndrome, it is recommended that trazodone not be used in combination with monoamine oxidase inhibitor therapy (MAOI therapy) or within 14 days of discontinuing treatment with an MAOI. 5.3 Screening Patients for Bipolar Disorder and Monitoring for Mania/ Hypomania A major depressive episode may be the initial presentation of bipolar disorder. Bipolar disorder is primarily about manic symptoms. Trouble Falling Asleep. Trazodone did not. If you have trouble falling asleep, you should take your Trazodone about three hours before bedtime. Though it can work, should you take trazodone for insomnia? Bipolar medications address the full spectrum of bipolar symptoms. The four trials that measured sleep efficiency found no benefit of trazodone over placebo. SSRIs produce a lot of sexual side effects, blocking ejaculation and erection. There are two misconceptions that must be clarified: 1. Its sedative effects tend to wear off over time, and it comes with risks including daytime fatigue, reduced recovery rates in depression (a paradoxical phenomenon seen in adolescents), 1 and dry mouthâ which itself may interfere with sleep. Trazodone also has limitations. Trazodone is a prescription drug for treating depression. I felt so great everyday when I took them, I would always take them 9pm at night, then get tired half an hour after taking them. Find patient medical information for trazodone oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Trazodone may also not be appropriate for people who have psychiatric illnesses, including bipolar disease and schizophrenia, as well as in those at risk for suicide. It should be noted that trazodone is not approved for use in treating bipolar depression. Trazodone (trade name Desyrel) is a very old antidepressant of the Tricyclic class.Trazodone is actually not an antipsychotic due to the fact that it has no effects on Dopamine or Epinephrine. Learn about side effects, warnings, dosage, and more. Trazodone is non-addictive, and it is quite inexpensive, which make it a popular choice for doctors to prescribe. It does, however, antagonize Alpha adrenergic receptors which is … I was ready for the day at 7am. Trazodone is a widely used but little-known drug prescribed off-label to treat insomnia, Consumer Reports notes. 2. 1.   Use trazodone with caution if you have heart or cerebrovascular disease, seizures, or kidney or liver problems. Three trials reported on perceived sleep quality, which was significantly better with trazodone than with placebo. Trial participants randomized to receive trazodone took the drug for a mean 1.7 weeks in doses ranging from 50 to 150 mg/day. “Trazodone helped me so much, I felt a boost in my confidence, I slept better at nights and my energy levels were so high. For example, bipolar depression symptoms are over three times more common than bipolar mania. Trazodone makes you feel drowsy, and when taken before going to bed it can help you to drop off to sleep. The concomitant use of trazodone hydrochloride tablets with serotonin precursors (such as tryptophan) is not recommended. It comes as an oral tablet and as a generic drug only. SSRIs can provoke weight gain over time. It's been over a year since this post, and even though I hate to bump an old thread, I thought this deserved an update. It definitely helped with sleep. 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